Regulators have found that clots are extremely rare, and that the benefits of the vaccines outweigh the risks. VITT refers to a rare combination of thrombosis (usually CVST) and thrombocytopenia which have been found in some patients 4 to 30 days after they receive their first AZ or JJ vaccine dose (and occasionally after their second dose). Vaccine safety has become an important issue due to Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT), also known as Vaccine-induced Immune Thrombocytopenia and Thrombosis, which has resulted in cases in recipients of the Oxford/AstraZeneca (AZ) and Johnson & Johnson (JJ) vaccines. However, they did not tackle the question of whether the findings of EC damage from S protein might also have an unintended negative side effect of reducing vaccine safety. Lei et al. noted that their conclusions suggest that vaccine-induced antibodies “not only protects the host from SARS-CoV-2 infectivity but also inhibits S protein-imposed endothelial injury”. They concluded that “S protein alone can damage vascular endothelial cells (ECs) by downregulating ACE2 and consequently inhibiting mitochondrial function”. Lei et al. created a pseudovirus surrounded by a SARS-CoV-2 crown of spike (S) proteins, but did not contain any actual virus, and found that exposure to this pseudovirus resulted in damage to the lungs and arteries of an animal model. Earlier studies of other coronaviruses have suggested that their spike proteins contributed to damaging vascular endothelial cells. However, there is now a growing consensus that SARS-CoV-2 also attacks the vascular system. BackgroundĬOVID-19 has been widely understood to be a respiratory lung disease. Overall, we conclude that spike proteins encoded by vaccines are not harmful and may be beneficial to vaccine recipients. We show that there is no known mechanism by which the spike protein impairment of endothelial function could reduce vaccine safety, and that vaccine safety data clearly shows that the spike proteins in vaccines does not reduce vaccine safety. The authors noted that their results suggest that “vaccination-generated antibody and/or exogenous antibody against S protein not only protects the host from SARS-CoV-2 infectivity but also inhibits S protein-imposed endothelial injury”. Lei et al. showed the spike protein in SARS-CoV-2 alone was enough to cause damage to lung vascular endothelium. Therefore, we’ve decided to make the paper available prior to review below (as HTML) and here (as PDF). Unfortunately peer review has taken months, so it’s still not published. Uri and I decided to set the record straight, and we wrote a paper that explains that “SARS-CoV-2 Spike Protein Impairment of Endothelial Function Does Not Impact Vaccine Safety”. That’s because it got widely picked up by anti-vaxx groups that totally misunderstood what it says. My colleague Dr Uri Manor was a senior author on a study in March this year which has become the most discussed paper in the history of Circulation Research and is in the top 0.005% of discussed papers across all topics. Adenovirus Vector-Based Vaccines and VITT.Mechanism of genetically-encoded spike protein vaccines.
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